Blar i forfatter "Bilger, Angelika"

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    • Hippocampus-avoidance whole-brain radiation therapy with a simultaneous integrated boost for multiple brain metastases 

      Popp, Ilinca; Rau, Stephan; Hintz, Mandy; Schneider, Julius; Bilger, Angelika; Fennell, Jamina Tara; Heiland, Dieter Henrik; Rothe, Thomas; Egger, Karl; Nieder, Carsten; Urbach, Horst; Grosu, Anca-Ligia (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-06)
      <i>Background</i> - The current study was aimed at investigating the feasibility of hippocampus‐avoidance whole‐brain radiation therapy with a simultaneous integrated boost (HA‐WBRT+SIB) for metastases and at assessing tumor control in comparison with conventional whole‐brain radiation therapy (WBRT) in patients with multiple brain metastases.<p> <p><i>Methods</i> - Between August 2012 and December ...

    • Local Control and overall survival after frameless radiosurgery: A single center experience 

      Bilger, Angelika; Frenzel, Florian; Oehlke, Oliver; Wiehle, Rolf; Milanovic, Dusan; Prokic, Vesna; Nieder, Carsten; Grosu, Anca-Ligia (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-06)
      <p><i>Introduction</i> Stereotactic radiosurgery (SRS) has been increasingly advocated for 1–3 small brain metastases. The goal of this study was to evaluate the clinical results in patients with brain metastases treated with LINAC-based SRS using a thermoplastic mask (non-invasive fixation system) and Image-Guided Radiotherapy (IGRT).</p> <p><i>Material and Methods</i> In this single-institution ...

    • Local control and possibility of tailored salvage after hypofractionated stereotactic radiotherapy of the cavity after brain metastases resection 

      Bilger, Angelika; Bretzinger, Eva; Fennell, Jamina; Nieder, Carsten; Lorenz, Hannah; Oehlke, Oliver; Grosu, Anca-Ligia; Specht, Hanno M.; Combs, Stephanie E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-09)
      In patients undergoing surgical resection of brain metastases, the risk of local recurrence remains high. Adjuvant whole brain radiation therapy (WBRT) can reduce the risk of local relapse but fails to improve overall survival. At two tertiary care centers in Germany, a retrospective study was performed to evaluate the role of hypofractionated stereotactic radiotherapy (HFSRT) in patients with brain ...

    • Long-term survival results after treatment for oligometastatic brain disease 

      Nieder, Carsten; Hintz, Mandy; Popp, Ilinca; Bilger, Angelika; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-04)
      Aim - The aim of this study was to characterize the survival results of patients with up to four brain metastases after intense local therapy (primary surgery or stereotactic radiotherapy) if extracranial metastases were absent or limited to one site, e.g. the lungs.<p> <p>Background - Oligometastatic disease has repeatedly been reported to convey a favorable prognosis.<p> <p>Material and ...

    • Validation of the graded prognostic assessment for gastrointestinal cancers with brain metastases (GI-GPA) 

      Nieder, Carsten; Hintz, Mandy; Popp, Ilinca; Bilger, Angelika; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-13)
      <i>Purpose</i> - The purpose of this study was to validate a new prognostic model (GI-GPA) originally derived from a multi-center database (USA, Canada, Japan).<p><p> <i>Patients and Methods</i> - This retrospective study included 92 German and Norwegian patients treated with individualized approaches, always including brain radiotherapy. Information about age, extracranial spread, number of brain ...

    • Validation of the graded prognostic assessment for lung cancer with brain metastases using molecular markers(lung-molGPA) 

      Nieder, Carsten; Hintz, Mandy; Oehlke, Oliver; Bilger, Angelika; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-26)
      Background:<br>Many patients with brain metastases from non-small cell lung cancer have limited survival, while others survive for several years, depending on patterns of spread, EGFR and ALK alterations, among others. The purpose of this study was to validate a new prognostic model (Lung-molGPA) originally derived from a North American database.<br>Patients and methods:<br>This retrospective study ...

    • Validation of the Graded Prognostic Assessment for Melanoma Using Molecular Markers (Melanoma-molGPA). 

      Nieder, Carsten; Hintz, Mandy; Bilger, Angelika; Oehlke, Oliver; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03)
      Background: It has been suggested to replace the diagnosis-specific graded prognostic assessment (DS-GPA, based on performance status and number of brain metastases) for patients with primary malignant melanoma with the new Melanoma-molGPA. The latter is a more complex assessment, which also includes BRAF mutation status, age and extracranial metastases. To test the performance of the Melanoma-molGPA, ...